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For each replication and each setting of the experiment a set of 2000 genotypes was generated using the R Package "hypred" (Technow 2013), starting by randomly mating two founders with three chromosomes each of length 1 M and 1000 markers per chromosome.

For each replication of the experiment a set of 500 , 750 1000, or 1500 genotypes was generated using the R Package hypred (Technow 2013), starting by randomly mating two founders with three chromosomes each of length 1 M and 1000 markers per chromosome.

The population size of 1,000 for generation 2 to 6 was obtained by randomly mating each male with 10 females and each female produced two offspring.

In the first step, we used the founder individuals to generate offspring by randomly mating the individuals.

We generated genotypes for additional 190 individuals by randomly mating the original 60 individuals on the CEU panel.

We generate simulation by randomly mating individuals and generating a pedigree using a recombination rate of 10−.

Table 1, shows how the new offspring is created by mating two parents using single point crossover.

Constructing hybrid strains by mating two mating competent diploid parents has been described previously [ 48].

Mating was performed by defining a population of 1000 viable networks and mating two randomly drawn networks at a time.

After the first generation, the siblings were randomly mated during ten generations before performing the experiments.

CEPH and YRI founders were then separately and randomly mating for 20 generations to generate two discrete subpopulations.