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For example, the effectiveness of an intervention can be assessed by randomized controlled studies or by case-control studies.
If as suggested by randomized, controlled studies, the placebo response approaches that of the drugs, the individual psychiatrist really has no way to tell whether patients are better because of the drug or simply because they have been prescribed a drug.
Whether those patients should benefit for increased dosing regimens should be evaluated by randomized controlled studies.
The laser hair comb is not backed by randomized, controlled studies done by independent researchers, says Dr. Paul Cotterill, president of the International Society of Hair Restoration Surgery.
Whether a negative association between statin use and mortality in Gram-negative BSI really exists as a biological interaction should be further investigated, preferably by randomized controlled studies (RCTs).
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High dose intravenous immunoglobulins (IVIG), able to neutralize these toxins, are frequently used even tough evidence of its efficacy is not supported by randomized controlled study (RCT).
Although HF has become a popular treatment option for homeless adults with mental illness, to date the program has only been assessed by a few randomized controlled studies and has not been widely evaluated outside the United States [ 11, 12, 20, 22, 23].
Meta-analysis was carried out by incorporating double-blind randomized controlled studies done on the efficacy of alogliptin in patients with type 2 diabetes.
The reliability of these results is limited by the small number of randomized controlled studies.
Quite all meta-analyses modulated their conclusions by addressing the need for large randomized controlled studies.
Future updated studies, especially large-scale randomized controlled studies stratified by region, are warranted as validation studies.
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