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These short motifs arise by evolutionary convergence, i.e. by random mutations and functional selection, rather than duplication and subsequent divergent spread in the genome, such as in the case of binding domains [59].
Therefore, quantitative differences appear to be due to subtle phenotypic and genotypic changes in the complex physiology of the mouse strains, which have been separated by inbreeding for many generations (compare Ref. 12 and the literature cited therein for divergence by random mutations and various phenotypic differences documented for congenic strains).
Short microsatellites are probably generated by random mutations and then expanded by DNA polymerase slippage.
Short SSRs are probably generated by random mutations and then expanded by DNA polymerase slippage.
Pseudogenes in bacteria genomes are non-functional copies of gene fragments usually created by random mutations and chance events [ 39, 40].
I am thinking of the early papers by Moolgavkar and the more recent models by Murray et al, Speer et al and Nowak et al. Author response: Cancer is certainly a stochastic process affected by random mutations and cell proliferation.
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It remains speculative how the genomic changes arise at the corresponding environmental response gene loci, simply by random mutation and sexual recombination, or by another internal spontaneous mutator?
BIOLOGICAL evolution happens by random mutation and selection.
But once the revolution begun by Darwin had advanced a bit, most Christians found it morally easier and far more comfortable to leave God's will out of it, and ascribe the fine detail of life's glories and discomforts to the accidents of evolution by random mutation and natural selection.
These criticisms converged on the issue of how to explain evolution of complex organisms solely by random mutation and selection.
Deregulation of allosteric inhibition of enzymes is a challenge for strain engineering and has been achieved so far primarily by random mutation and trial-and-error.
More suggestions(16)
by random errors and
by random defects and
by additional mutations and
by random disturbances and
by random trivia and
by different mutations and
by random vibrations and
by random processes and
by random events and
by such mutations and
by genetic mutations and
by random stabbings and
by random associations and
by convergent mutations and
by particular mutations and
by random demands and
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