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According to the theory of neutral variation, most of the genetic variability within species are caused by random drift of selectively neutral polymorphic alleles [3].
Heteroplasmic mutations might have accumulated in cancer cells by random drift of a pre-existing heteroplasmy (Nekhaeva et al, 2002).
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The inflated D' estimates between non-syntenic SNPs with rare alleles are probably due to the effect of sampling caused by random drift or the loss of rare haplotypes in sampling in the present study.
Neutral drift is the process of change of genotypes by random drift without phenotypic alteration, and is used to describe the process of acquiring higher-order structure of nucleic acid sequences.
Here it is often difficult, without examining each substitution individually, to distinguish which mutations result from selection and which are caused by random drift, and the relative importance of each mutation with respect to fold and function [33].
Finally we should mention that the elimination of satellites by random drift may not be sufficiently effective to result in the complete disappearance of large satellite families, which may have hundreds of members: an additional mechanism might be required.
The absence of a detectable phylogenetic signal may be the consequence of such selection that has overridden phylogenetic structure in SShD or, alternatively, it may be the result of evolution by random drift (e.g., in association with speciation and founder events).
The quasispecies nature of mutant RNA clouds facilitates the recovery of genotypes under pressure of being removed from the population by random drift.
" "Many regulatory elements evolve due to mutations, insertions and deletions of nucleotides (by selection, or by random drift), or due to transposable elements".
It may be neutral (s ≈ 0), that is, having such a small effect on fitness that the fate of the mutant is mostly determined by random drift.
Mutations are affected mostly by random drift when the selection coefficient (s) is less than the reciprocal of the effective population size (|s|<1/Ne) [44].
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