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This analysis assessed which amino acids in a family varied by random drift from those that have been subjected to purifying or diversifying selection.
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This negative frequency-dependent selection prevents a single allele from fixating by random drift as expected under neutral evolution.
The quasispecies nature of mutant RNA clouds facilitates the recovery of genotypes under pressure of being removed from the population by random drift.
Genotypes that are closely connected by short Hamming distances are closely related in the sense that they can rapidly (e.g., in a few generations) be regenerated from one another in the eventual case of being removed from the population by random drift.
Here it is often difficult, without examining each substitution individually, to distinguish which mutations result from selection and which are caused by random drift, and the relative importance of each mutation with respect to fold and function [33].
In small compartments, genetic instability, which confers a selective disadvantage for the cell, can spread by random drift.
Neutral alleles are those that differ so little in fitness that their frequencies change by random drift rather than by natural selection.
Of course, many beneficial mutations are lost by random drift while they are rare.
Heteroplasmic mutations might have accumulated in cancer cells by random drift of a pre-existing heteroplasmy (Nekhaeva et al, 2002).
The junk DNA hypothesis suggests that these extra DNAs are useless, maladaptive DNAs and fixed by random drift [ 43].
Many regulatory elements evolve due to mutations, insertions and deletions of nucleotides, by selection, duplication, inversion, translocation or by random drift, or due to transposable elements.
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