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The SV protein or protein domain will eventually find itself in an endoplasmic reticulum export site (ERES), either by random diffusion or by interacting with elements stabilized in these areas, for example coat proteins involved in ER-to-Golgi ER-to-Golgi ER-to-Golgi
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Furthermore, organisms move by random diffusion [ 44] and die with a constant probability (default 0.1).
Transcription Factors need to locate their target sites on the DNA within a time frame that is shorter than can be achieved by random diffusion.
The power of targeting by random diffusion within the nucleus is best illustrated when considering how a transcription factor finds its target genes but it also applies to targeting of proteins to nuclear compartments or any other nuclear site.
Concluding, we find that domain fusion is a tool to superannuate the random diffusive interaction of a domain pair by embedding them in an architecture which ensures their interactions that would be difficult by random diffusion in a cell alone.
The model and accompanying simulation results support the hypothesis that AMPARs can come from the pool of extrasynaptic receptors to cause LTP expression within the allotted time and by random diffusion alone.
The other mechanism is the random diffusion or surface diffusion effect.
Furthermore, the influence of the substrate temperature on the other morphological properties, such as diameter, length, and density, can be explained by the random diffusion effect.
The length of nanorods can also be influenced by the random diffusion effect since the expansion and the coalescence processes will reduce the growth rate of AgNRs.
Second, the morphological properties of AgNRs, such as diameter, density, and length, dependent on the substrate temperature as well as the existence of a critical temperature for the AgNR array formation can be explained by the random diffusion effect.
Although the size of LRP6-ICD (∼20 kDa) and AES (∼25 kDa) allow for nuclear diffusion [60], it is reasonable to assume the transcriptional activity of the Wnt pathway is not modulated by the random diffusion of effector proteins.
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