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The model and accompanying simulation results support the hypothesis that AMPARs can come from the pool of extrasynaptic receptors to cause LTP expression within the allotted time and by random diffusion alone.
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Concluding, we find that domain fusion is a tool to superannuate the random diffusive interaction of a domain pair by embedding them in an architecture which ensures their interactions that would be difficult by random diffusion in a cell alone.
Furthermore, organisms move by random diffusion [ 44] and die with a constant probability (default 0.1).
Transcription Factors need to locate their target sites on the DNA within a time frame that is shorter than can be achieved by random diffusion.
In larger fragment or full-length models, huntingtin is capable of nuclear entry via the PY-NLS sequence and not by simple diffusion alone.
Using experimental models, cancer biologists observed that blood vessels were essential to support tumor growth beyond the size allowed by oxygen diffusion alone [5].
The vertebrate cardiovascular system is designed to move a variety of molecules over considerable distances throughout the body faster than they would move by diffusion alone.
Local endovascular drug delivery was long assumed to be governed by diffusion alone [25], [26].
Although the size of LRP6-ICD (∼20 kDa) and AES (∼25 kDa) allow for nuclear diffusion [60], it is reasonable to assume the transcriptional activity of the Wnt pathway is not modulated by the random diffusion of effector proteins.
Folates are hydrophilic anionic molecules that do not penetrate biological membranes by diffusion alone.
Fundamental to all these considerations is that bacteria must accumulate nutrients that reach them by diffusion alone [ 7].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com