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AZOrange is intended to aid in developing models compliant with the OECD principals for validation of QSAR models, by providing established methods for performance assessment and by granting the principal of transparency in being based solely upon Open Source codes.
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Taking endocrine disrupting chemicals and polychlorinated biphenyls as the polar and weak polar model analytes, optimizing several parameters influencing the recoveries, limits of detection in the range of 0.01 0.11 ng mL−1 and 0.19 1.53 ng L−1 for the two series of compounds were provided by the established methods.
Data security is provided by a combination of established methods that cover regular backups and archiving as well as galvanic isolation of the server by an uninterruptible power supply.
Lactational differentiation was induced by established methods [73].
Liver cytosols were prepared by established methods (36).
ENMG and QST were performed by established methods [38].
DNA probe testing was performed by established methods (4 ).
Reference intervals were established for haematologic and biochemical analytes on the Advia 2120i™ and the Dimension ExL™ by established methods.
Our results show that this method can provide susceptibility values which agree well with values obtained from other established methods, while additionally providing population statistics not available by the other methods.
Ki-67, p53 and ER immunohistochemistry, and Her-2/neu amplification analysis by CISH involves simple, standardised and established methods that can provide valuable prognostic information on T1N0M0 breast cancer.
For such a short-term projection (3 years), most established methods will provide very similar results.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com