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When we defined p53 status by protein expression status, we found no substantial heterogeneity in the ORs for the associations between PAH-related exposures and p53-positive cancer and the corresponding PAH exposures and p53-negative breast cancer [all p-values > 0.05 for the ratios of the ORs; see Supplemental Material, Table 3 (doi:10.1289/ehp.0901233)].
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OBJECTIVE: To evaluate the potential etiologic heterogeneity of breast cancer by examining whether associations with reproductive and other personal characteristics differed by p53 protein expression status.
Whether this association varies by the tumor protein expression status of the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), or p53 is unclear.
Polytomous logistic regression (Hosmer and Lemeshow 1989) was also used to estimate the ORs and 95% CIs for associations between breast cancer categorized by tumor p53 protein expression status and these same PAH-related factors.
Although previous studies have examined whether the physical activity-breast cancer association varies by the tumor protein expression status of the estrogen receptor (ER) and the progesterone receptor (PR) 2– 23, little is known as to whether the association varies by the human epidermal growth factor receptor 2 (HER2) or p53.
Here we examine whether the benefits of physical activity vary by the tumor protein expression status of ER, PR, HER2, and p53 in order to provide greater insight into biological mechanisms underlying the association between physical activity and risk of breast cancer.
PTEN protein expression status by IHC on 3- μm tissue sections was performed and evaluated according to the literature (Frattini et al, 2005; Saal et al, 2005).
There was no difference in outcome by EGFR expression level or MMR protein expression status.
SDH protein expression status was evaluated by both immunohistochemistry (IHC) of SDHB and SDH subunits sequencing.
Protein expression status of KIT and PDGFRA was performed by immunohistochemistry of tissue microarray containing 522 serous ovarian carcinomas.
The FASN protein expression status tended to be correlated with growth inhibition by the C75 FASN inhibitors.
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