Sentence examples for by protein expression data from inspiring English sources

This suggestion is supported by protein expression data [ 54], and the discovery that mutations in this gene in human Mitchell-Riley syndrome are associated with duodenal and jejunal atresia [ 52].

By overlapping protein expression data to transcriptome data, we identified the AM genes with transcriptome alterations mirroring their proteome dysregulation (Table 7).

Based on the model version of optimized parameters, gained in the simultaneous model fit, the effect of inter-individual variability of CYP3A4 and UGT1A3 protein expression levels was investigated by linking the protein expression data of 150 liver samples via the described relative abundance approach in equation (11), using individual 1 as reference.

In silico pathway analysis supported by mRNA and protein expression data delivers an explanation for how the miRNA-mediated downregulation of FZD5, TMEM92 and HNF1B could influence the canonical Wnt/ β-catenin pathway and the intercellular adhesion mediated by the cadherin/catenin Complex.

Thus, the novel premise is that the gene expression array data is validated proteomically by the cytometry and the protein expression data identified by cytometry is validated by the gene expression profiling.

In this study, we used a systems biology approach to identify common metastatic pathways that are jointly supported by both mRNA and protein expression data in two distinct human metastatic OS models.

Similarly, the knock down of key autophagy regulators (ATG5 and Beclin1) by shRNA inhibits their protein expression (data not shown) and promotes pancreatic tumor cell death under hypoxic conditions, supporting a pro-survival role of autophagy in the hypoxic tumor microenvironment.

These results show that it is possible to connect protein expression data by immunohistochemistry with LC-MS lipidomic profiles of the identical tumors.

As immunoblotting procedures confirmed that Ctx-induced phospho-activation of FGFR3 was accompanied by increased steady-state FGFR3 protein expression (data not shown), our findings confirm and extend a recent study by Ware et al (2010) demonstrating that NSCLC cell lines rapidly acquire resistance to EGFR TKIs and Ctx through transcriptional de-repression of FGFR2 and FGFR3 expression.

Thus, GEP correlates to protein expression data revealed by multiparameter flow cytometry.

Coupling the GPR with a metabolic model is a starting point for several algorithms designed to refine metabolic models by integrating high-throughput gene or protein expression data.