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More importantly, AMF inoculation ameliorated inhibitory effects of ZnONPs by promoting secretion of glycoprotein called glomalin a potent metal chelator within the rhizosphere, which significantly reduced (by almost half) Zn uptake by root and subsequent translocation to the shoot.
Defensins can also stimulate an antiviral state in cells by promoting secretion of chemokines [ 76].
This outcome thus compares favourably with the effects of repertaxin, which causes death also of CXCR1-negative cells by promoting secretion of Fas ligand (Ginestier et al, 2010).
In addition, IL-7 has been shown to induce bone loss by promoting secretion of RANKL (receptor activator of nuclear factor-κB ligand), a cytokine responsible for the formation of osteoclasts, from T cells [ 14].
In addition, interaction of CR1 with its ligands plays further roles in regulation of lymphocyte (L) activity by promoting secretion of interleukin (IL -1α, IL -1α and prostaglandins [ 13].
Studies have shown that chemotherapies do not efficiently target CAFs for cell death but rather enhance the tumor promoting activities of fibroblasts by promoting secretion of growth factors and cytokines [ 24, 25].
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Additionally, αB-crystallin has also been implicated in regulation of physiological and pathological angiogenesis by stabilizing and promoting secretion of vascular endothelial growth factor A (VEGF-A) [ 5, 6].
Senescent cells secrete HMGB1 promoting secretion of inflammatory cytokines (TNFα, IL-1β and IL-6) by macrophages [ 55].
Research on such special abilities of PDRN and trials to use it for treatment by working it on fibroblasts and promoting secretions of cell growth factor, as well as for beauty and wound healing, are active across the surgical field.
Additionally, it has been recently identified a novel transcription factor encoded by the rv3849 gene which promotes secretion of ESX-1 substrates, including ESAT-6 [36], and hence was renamed EspR, an acronym for ESX-1 secreted protein regulator.
Thus, drugs that arrest ulcer progression by antioxidant action, and also promote secretion of PGE2, gastric mucus, and growth factors would accelerate gastric ulcer healing.
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