Sentence examples for by prolonged activation of from inspiring English sources

These effects were also unlikely to have been mediated by prolonged activation of forebrain regions per se since prolonged stimulation of posterior hypothalamic sites, which also potently activated forebrain EEG in a similar way, did not disturb subsequent state alternations (Figure S2).

Though it is not known whether the c-SRC gene in DF-1 cells is mutated or not, the increased expression of c-SRC in DF-1 CEF cells suggests a contribution to the immortalization of the cell by prolonged activation of growth signal and the anti-apoptotic activity.

This implies that changes in the organization of heterochromatin contribute to the cell cycle arrest that is induced by prolonged activation of the Raf/ERK pathway.

In immune cells, TLR expression is generally inhibited by prolonged activation of NFκB [ 45].

TNF-α stimulates collagenase gene transcription by prolonged activation of Jun gene expression in fibroblasts [ 63].

The organoid formation by PC12 pheochromocytoma cells in a RWV bioreactor is accompanied by prolonged activation of the ERK, p38, and jnk signaling pathways [ 97]. 3D cell culture techniques have attracted much attention, not only among biologists, but also clinicians interested in tissue engineering [ 98, 99] of artificial vessels [ 100– 104] or cartilage [ 105– 108].

The activation of DUSP1 seems to counterbalance the inflammatory response to PAR (protease-activated receptors) activation by avoiding prolonged activation of p38 MAPK and increased cytokine production in the rat urinary bladder, which was revealed using IPA [35].

Therefore, the neuroprotective function of APP/sAPP α is likely to be mediated by the prolonged activation of cell survival signaling pathways.

In this context, the activation of genes such as dusp1 and nfkbia seems to counter balance the inflammatory response to PAR activation by avoiding prolonged activation of p38 MAPK and increased cytokine production [ 68].

This suggests that nuclear translocation of Trx1 may be a useful therapeutic target to prevent severity of disease caused by excessive or prolonged activation of redox-sensitive transcription factors.

mTOR has a central role as a regulator of cell death induced by overactivation or prolonged activation of autophagy.