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We observed that TDP-43-induced lethality was preceded by progressive impairment of locomotor activity and wing posture (Video S1).
Alzheimer's disease (AD), a very common neurodegenerative disease, is characterized by progressive impairment of cognitive function and memory formation.
Aging is characterized by progressive impairment of carbohydrate intolerance and is usually accompanied by physical inactivity and obesity, which may induce hyperinsulinemia, insulin resistance, and cardiovascular disease (1).
bvFTD is a clinical syndrome characterized by progressive impairment in behavior and personality as well as social, cognitive, and functional abilities, which predominantly affects middle-aged adults [ 1, 2].
Bayir and collaborators showed that children, who have suffered severe TBI, presented a clinical evolution that is marked by progressive impairment in antioxidant defenses and increase in lipid peroxidation.
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are among the most common types of dementia, and both are characterized by progressive impairment of cognitive, behavioural, and daily functioning [ 1, 2].
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Clinically, AD is characterized by progressive impairments of memory, judgment, decision making, orientation to physical surroundings, and language.
AD is defined by progressive impairments in memory and cognition and by the presence of extracellular neuritic plaques (A β) and intracellular neurofibrillary tangles (tau protein) [ 5, 32].
Normal aging is accompanied by progressive impairments of the cardiovascular and circulation systems 8 characterized by adaptational difficulties in stressful situations (financial years, care), extremes for subjects with dementia.
PD is manifested by (1) severe motor symptoms characterized by a progressive impairment of movement control, akinesia, rigidity, and tremor; and (2) nonmotor symptoms such as cognitive decline, olfactory dysfunction, anxiety [ 95], and depression [ 96].
The progression of Duchenne muscular dystrophy (DMD) is characterized by a progressive impairment of muscle function leading to death due to cardio-pulmonary failure in the late teens or early twenties [1], [2], [3].
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