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Generally speaking, neurodegenerative diseases are characterized by progressive declines in behavioural and neural function, often manifest through a pathogenic process in a maladaptive cycle.
Aging is characterized by progressive declines in the physiology and functionality of adult tissues and can manifest nine common hallmarks: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intercellular communication.
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Alzheimer's disease (AD) is the most common neurodegenerative disorder, marked by progressive decline in memory and cognition over decades.
Posterior cortical atrophy (PCA) is a neurodegenerative syndrome that is characterised by progressive decline in visuospatial, visuoperceptual, literacy, and praxic skills.
Furthermore, the development of IGT was characterized by progressive decline in the DI (Fig. 2 B).
It is characterized by progressive decline in forced expiratory volume (FEV1).
Alzheimer's disease (AD) is the most common cause of senile dementia characterized by progressive decline in cognition and behaviors.
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by progressive decline in cognitive and functional abilities.
FTLD is characterized by progressive decline in behavior, personality, or language, symptoms that are attributed to the degeneration of the frontal and temporal lobes.
Alzheimer's disease is a common neurodegenerative disease characterised by progressive decline in cognitive, social, and occupational function, and often associated with affective symptoms and behavioural disturbances.
The syndrome is led by progressive decline in personality and inter-personal skills with emergence of a range of behavioral abnormalities including obsessionality, loss of empathy and apathy [Rascovsky et al., 2011].
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