Progesterone regulates genes that are involved in RNA and protein processing, cell cycle, apoptosis, and cellular metabolism [ 79].
Proteases are also implicated in heat shock response, signal peptide processing, cell cycle progression, transcriptional regulation, and signal transduction networks.
At the end of each treatment time, cells were collected after a brief incubation with trypsin EDTA followed by processing for cell cycle analysis as reported earlier [ 14].
This analysis further predicts changes in cellular processes, cell cycle, RNA-processing and protein turnover as cells acquire neural fate.
Interestingly, by GO analysis we found that genes in group 1 tend to have functions in signal transduction, such as protein ubiquitination and phosphorylation, RNA processing, and cell cycle process (Table S5).
Significantly affected biological processes identified by ToppFun Suite software on affected genes were "RNA splicing and processing" and "cell cycle" (Table 2).
The most prominent groups of enrichment in class (ii) are RNA processing and cell cycle.
Interactome pathways also have interactions with nuclear transcription factor expression, immune system MHC processing and cell cycle regulatory proteins.
These privileged somatic cells exhibit ultrafast cell duplication and express higher levels of proteins involved in DNA repair, RNA processing and cell cycle control (Guo et al., 2014).
These findings are consistent with the concept that the early stages of OPCs differentiation are characterized by events modulating RNA processing [5], [31] [33], cell cycle control [34] [36], and down-regulation of transcriptional inhibitors of differentiation [13], [14].
