Geminin blocks the licensing of replication origins by preventing the Cdt1-mediated loading of Mcm2 7 onto chromatin [15, 16].
First, PIs suppress HIV-1 PR by preventing the assembly of mature virion, thus preventing viral replication and decreasing viral load.
Alternatively, sumoylated Rpb1 may recruit additional factors, which may in turn prevent the loading of a damage sensor to the ssDNA generated by damage-stalled Pol II.
The two designs of implant incorporated modifications to the geometry of the design intended to improve postoperative ROM and provided safe and adequate flexion by preventing loading on the edge of the posterior tibial articular surface and by increasing the tibiofemoral contact area during high flexion [ 8, 20].
Thus, in addition to activating DNA damage signaling, ATM may avert chromosome translocations by preventing excessive loading of recombinational repair proteins onto translocation breakpoint hotspots.
The friction can prevent the large loads caused by high pressure and/or high temperature from spreading so that only a small part of tubing deforms severely.
Short-stemmed implants were introduced with the aim of preserving proximal bone stock for future revisions by preventing stress shielding through metaphysical bone loading.
The author in [15] uses a proactive load sharing scheme for distributed systems which prevents the occurrence of load imbalance by collecting load and task execution behavior information in advance.
The inhibition of Dopa decarboxylase by carbidopa prevents the response of dopamine to sodium loading in both rats and humans and stimulates Na+, K+-ATPase activity [ 14, 26].
One of the novel features of this study is that the size of the incentive is linked to future costs averted by preventing HIV infections due to greater viral load reduction.
