Sentence examples for by preventing activation of from inspiring English sources

To confirm that YopJ blocks the HOG pathway in a manner similar to that observed for the mammalian MAPK pathways by preventing activation of MKKs, we generated a yeast strain that contained an activated form of yeast MKKK Ssk2 (Ssk2ΔΝ) under the control of a galactose inducible promoter (Figure 1B) [1B].

In vitro data with human blood and in vivo mouse studies indicate that it can inhibit the production of cytokines triggered by inflammatory stimulators by preventing activation of a transcriptional regulatory protein called STAT3.

Blocking CDC25 function directly inhibits cell division by preventing activation of the cell cycle engine.

Likewise, NURF also inhibits lamellocyte differentiation, in this case by preventing activation of targets of the JAK/STAT pathway [19].

In contrast, blocking Cdc25 function inhibits cell division directly by preventing activation of the cell cycle engine.

NS1 is responsible for suppressing antiviral interferon (IFN) induction during viral replication by preventing activation of the latent transcription factors IRF-3 [25] and NF-κB [26].

PTEN is a tumor suppressor protein that reverses the reaction catalyzed by PI3K, preventing activation of downstream effectors.

Similarly, vaccinia virus encodes a mitochondrially targeted protein, F1L, which is able to inhibit apoptosis by binding and preventing activation of Bak and Bim (Wasilenko et al., 2005; Postigo et al., 2006; Taylor et al., 2006).

Etanercept inactivates circulating TNF-α by binding to it, thereby preventing activation of endogenous TNF-α receptors.

The MUC1 extracellular domain makes a substantial contribution to this effect by maintaining the integrity and preventing activation of the cell surface anoikis-initiating molecules.

This buffering by SERCA prevents activation of CCE during brief applications of CCh, allowing EC to sustain Ca2+ oscillations in Ca2+-free solution for 15 20 min.