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A strong upregulation of NCED4 was accompanied by preferential expression of transcripts encoding ABA-responsive proteins (At2g40170, At3g02480, At5g62490).
In principle, the deleterious effects of these mutations could be suppressed in a diploid organism by preferential expression of the reference allele.
For example, in WT we encountered a clear induction of glycolysis and fermentation (FBP aldolase, PFK, PDC1, ADH1) as well as strongly induced nitrogen assimilation as suggested by preferential expression of NIA2 and NiR1.
In a parallel "consensus cluster" classification developed by Monti et al. [ 15], it was shown that DLBCL could be divided into three categories characterized by preferential expression of genes linked to proliferation and B-cell receptor signalling, metabolic oxidative phosphorylation, or host response.
The llama newborn demonstrates significantly greater α-adrenergic peripheral vascular reactivity compared with neonates from lowland species that could be partially explained by preferential expression of α1B-adrenergic receptor subtype. the llama, a south american Camelidae (Lama glama), has evolved in the low O2 milieu of the Andean altiplano at altitudes > 4,000 m above sea level.
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This is confirmed by the transcription of the Hprt1 WT alleles from the Xist-coated X-chromosome in a significant percentage of cells of these clones (as determined by RNA-FISH) and by a preferential expression of maternal alleles of other X-linked genes as assessed both by allelic RT-qPCR and by RNA-FISH (see Additional file 2B, C).
These high levels of circulating sCTLA-4 in SpA were not explained by altered intracellular expression of CTLA-4, but by a preferential expression of the spliced form of CTLA-4 transcripts, a result that was not observed in RA.
This conclusion is supported by the preferential expression of TLR8, which is present at much higher levels than TLR7, on CD14+ MLN cells.
We showed in the results section (Additional file 5) that differences between genotypes may be accounted for by the preferential expression of different members or splicing forms of genes from the same family.
Such variation could be explained by a hierarchy of preferential expression of different alleles, as is seen for the X-linked Xce locus [37].
Previous studies by others have reported preferential expression of Coup-tfII in the atrial myocardium of the mouse heart (Pereira et al, 1999), but no data are available for Coup-tfI.
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