Upon further filtering by potency (cutoff of IC50<10 µM and cluster size greater than 4), a total of 157 representative compounds spanning 17 chemical clusters and 83 singletons were prioritized for further studies.
These findings suggest that osteogenic mediators induced by TLR2 signaling could be negatively affected by the potency of the inflammatory response mediated by strong TLR4 responses and cytokines such as TNF-α.
In order to determine how osteogenesis mediated by TLR2 is affected by the potency of the inflammatory response, TNF-α was simultaneously added in doses from 0 100 ng⋅mL−1 to osteoblasts that were unstimulated or stimulated with either P3C or EcLPS.
Importantly, disease process kinetics can be controlled by the potency of GP-specific vaccinations or by controlling the transfused CTL number and activation state.
Thus, the net effect of TLRs on osteoclastogenesis in vivo is mediated by various cell types and is determined by the potency of pro-osteoclastogenic versus anti-osteoclastogenic mechanisms.
Nevertheless, the usefulness of producing single cecropin A peptides is not only determined by the level of accumulation in transgenic rice seeds, but also by the potency of cecropin A as an antimicrobial agent for the target pathogens without additional processing.
But such small weaknesses are outweighed by the potency of other relationships, which feel rich and terrifying — the Tower of London looms behind even the most innocent chitchat.
After the primary, the academics examined the voter rolls and were startled by the potency of peer pressure as a motivational tool.
Benjamin's memories come flooding back, triggered by the potency of this specific house -- until, later on, his aunt informs him that he was actually born in a house three doors away.
