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Furthermore, overexpression of UCP2 in several colon cancer cell lines is able to promote chemoresistance which is, at least in part, resulting from the inhibition of p53-induced apoptosis by posttranslational modification of p53 [19].
TrxG and PcG maintain transcriptional expression and repression antagonistically by posttranslational modification of histone.
RamC, the enzyme that generates the lanthionines in SapB by posttranslational modification of the RamS peptide, was the first class III synthetase identified.
AP-1 activity is regulated by induced transcription of c-Fos and c-Jun and/or by posttranslational modification of their products in mammals.
Diphthamide is a rare amino acid synthesized by posttranslational modification of a histidine residue on translational elongation factor 2 (EF2) that serves an essential role in ribosomal protein synthesis.
Future studies will undoubtedly shed light on the relative importance of protein arginine methylation and highlight cellular events that are controlled by posttranslational modification of L-Arg residues under physiological and pathophysiological scenarios.
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Cataract is a protein conformational disease caused by posttranslational modifications of the structural lens proteins [3].
Regulation of mammalian gene expression is facilitated in part by posttranslational modifications of histones that contribute to chromatin organization [26].
The reduction of specific force may be caused by posttranslational modifications of contractile proteins induced by ROS.
However, we cannot exclude the possibility of differences in StAR activity, which is regulated by posttranslational modifications of the protein [ 45].
Cellular and oxidative stress were shown to alter the activity of CRM1 and to affect the localization of polyQ proteins by posttranslational modifications of karyopherins or subsets of the nuclear pore complex [ 137].
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