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Recently, we concluded that skeletal genes demonstrated high population differentiation driven by positive selection, supporting the rapid evolution of skeletal system [17].
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By contrast, later stages of thymocyte differentiation appeared relatively intact, with changes within the DN population not affecting the number of DP cells generated and no defect in either β-selection or positive selection (Supporting Information Table 1).
This finding indicates that this particular position may be under strong positive selection supported by a high ω=1.7 and a low κ=1.2.
The alternative hypothesis that the higher sequence divergence in these regions is caused by positive selection for single nucleotide mutations was not supported by our analysis.
The 2Δln values supported the phenomenon that there were amino acid sites driven by positive selection in both TNL and non-TNL gene families (Tables 3 and 4).
Figure 1 demonstrates that 370A has a highly unusual worldwide frequency distribution, supporting a scenario in which the 370A allele was driven to high frequency in East Asians and Native Americans by positive selection (Figure 1).
Genes that have been changed by positive selection have significantly more protein-altering mutations.
We infer that this young haplotype has been driven to a high frequency by positive selection.
After washing, CD11c+ cells were purified by positive selection using MACS separation columns (Miltenyi).
The majority are clade-specific, with the wood clade having the largest number of gene ontologies impacted by positive selection.
From the CD11b column we isolated microglia by positive selection and astrocytes by depleting microglia.
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