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The dN/dS ratio is one of the most fundamental and powerful tests for identifying genes that have been affected by positive selection because it highlights loci with higher than expected rates of non-synonymous substitution.
In the future, it would be interesting to determine whether heart enhancers have been repeatedly shaped by positive selection because they are also involved in other developmental processes associated with morphological or physiological diversity.
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It is strongly suspected that the long-term persistence of certain MHC haplotypes is favored by their positive selection because of beneficial interactions between specific allelic products of the different loci composing these stable haplotypes during a long period (Beck and Trowsdale 2000).
This high proportion of rapidly evolved global jiDE genes is not caused by positive selection, but results from a lack of selection, because about two thirds of the random mutations in the ORFs of silenced genes induce non-synonymous changes.
While some new mutants have higher fitness than others and therefore are retained by positive selection, most mutations are quickly removed by purifying selection because they are deleterious [ 5, 6].
Thus, the mitochondrial genes of Glyptosternoid fishes may have experienced adaptively accelerated evolutionary rates to better adapt to the extreme environments of the Tibetan Plateau because accelerated evolution is usually driven by positive selection.
From the CD11b column we isolated microglia by positive selection and astrocytes by depleting microglia.
Because of these limitations we were only able to provide suggestive evidence for over representation of specific biological processes affected by positive selection.
Rapid evolution can mainly be explained by relaxation of purifying selection or by positive selection.
These patterns are caused primarily by positive selection, so our scan missed other types of selection.
In general, bottlenecks driven by positive selection were usually followed by a bottleneck driven by purifying selection.
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