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Likewise, the promoters of actively expressing genes in Homo sapiens also possess nucleosome-free TSS flanked by positioned nucleosomes [ 51].
Active genes have characteristic nucleosome depleted regions (NDRs) flanked by positioned nucleosomes upstream of their transcription start sites, which contain binding sequences for transcription factors [47].
Studies of budding yeast have discovered dinucleotides (AA/TT/AT) periodicity along nucleosome positioning sequences [ 7, 8]; and that nucleosome depleted regions (NDRs) are characterized by positioned stretches of poly (dA dT) tracts [ 9, 10].
More recently, a complete high-resolution map of nucleosome occupancy across the whole genome of yeast has shown that 81% of the yeast genome is covered by positioned nucleosomes [ 27].
Arrangement of nucleosomes in active state R3 is generated by the positions 1, 2 (or 3, 4), 5 and 12 giving a nucleosome-free region flanked by positioned nucleosomes.
DOI: http://dx.doi.org/10.7554/eLife.06073.014 The aggregate nucleosome profiles of wild type (blue line, Figure 5B) confirmed published observations (Yuan et al., 2005; Lee et al., 2007; Whitehouse et al., 2007), showing a clear NDR flanked by positioned nucleosomes (termed −1 and +1) and phased positioned nucleosomes within the proximal coding region.
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Ardern has challenged that by positioning the state as a force for imaginative and positive change.
Aung San Suu Kyi has said she will nevertheless rule the country by positioning herself "above the president".
"By positioning the pavilion here I am staking a claim for their nationhood".
By positioning diversity programs as discriminatory, Damore paints exactly the opposite picture.
London Metropolitan University already does this well by positioning itself as offering an affordable education.
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