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Despite its basic and clinical importance, the extent of ER stress inflicted by physiological and pathophysiological conditions remains difficult to quantitate, posing a huge obstacle that has hindered our further understanding of physiological UPR and its future therapeutic potential.
The endocrine pancreas is a plastic tissue able to expand or regress in response to the requirements imposed by physiological and pathophysiological states associated to insulin resistance such as pregnancy, obesity or ageing, but the mechanisms mediating beta cell mass expansion in these scenarios are not well defined.
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Its production is influenced by various physiological and pathophysiological stimuli [ 109, 110].
Competition between 7-oxysterols and glucocorticoids for metabolism by 11βHSD1 across physiological and pathophysiological concentration ranges was investigated using three preparations of murine enzyme.
Also in the recent study showed AdipoR1/R2 appears to be inversely regulated by insulin in physiological and pathophysiological states such as fasting/refeeding, insulin deficiency, and hyper-insulinemia models via the insulin/phosphoinositide 3-kinase/Foxo1 pathway and is correlated with adiponectin sensitivity[ 27].
Expression of the EP genes is regulated by various stimuli, both physiological and pathophysiological, resulting in variable levels of expression even in a given tissue.
The function and expression of Glut-1 is regulated by a number of physiological and pathophysiological conditions (Zhang et al, 1999).
MicroRNAs (miRNAs) are short ∼22 nt RNA molecules that bind to the transcripts of protein-coding genes to direct their post-transcriptional repression and by that regulate important physiological and pathophysiological signalling pathways.
Oxidation of arachidonic acid by PGHS is critical in numerous physiological and pathophysiological states (1, 2).
Cardiac extracellular matrix (ECM) remodeling is a process adapted by the heart to deal with physiological and pathophysiological hemodynamic changes.
PET enables in vivo visualization and quantification of physiological and pathophysiological processes by injecting positron emitting radionuclides that bind specifically to a target tissue.
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