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Deposition of Si around the endodermis provides the potential to control Cd apoplastic transportation by physically obstructing the apoplast bypass flow in the root [ 107].
In addition, by physically obstructing the contact with potential synaptic partners, astrocytes may hinder the formation of contacts with the most ensheathed boutons or guide nascent spines towards a specific presynaptic partner, as has recently been shown during the development of C. elegans connectivity (Colon-Ramos et al. 2007).
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In their complaint the violists charge that Fader has long intimidated them and other women in the orchestra "by glaring at them, by making inappropriate body movements, comments, grunting, sucking and 'tsh tsh' noises at them, by physically obstructing passage in the hallways and blocking access in and out of the viola section".
Pore blockers bind to the external vestibule of the channel and physically obstruct the movement of ions by occluding the ion-conducting pore.
An example of how binding of butein (cyan sticks) physically obstructs the placement of fatty acid (modeled as green sticks) in the substrate binding channel is shown.
DNA adducts will physically obstruct the polymerase and reduce product yield until the lesions have been removed or repaired.
Among the ~28 million CpG dinucleotide sites that are susceptible to methylation in the human genome, approximately 10% are in the promoter regions of genes, in which they may physically obstruct the binding of transcriptional proteins to the gene or may be indirectly regulated by the recruitment of methyl-CpG-binding domain proteins through cytosine methylation [ 14- 16].
However, upon sialylation of TcTS, the WAT_1 site is physically obstructed by the sialyl residue and is absent.
The fluid, rolling momentum of their choreography is physically obstructed by the furniture on stage, across which they have to navigate a balancing, spinning, toppling path.
The latter involves chelated gadolinium surrounded by an enzyme substrate, which physically obstructs water molecules from approaching the gadolinium.
The specific mode of AChE interaction with PrP fibrils, as detailed before, may physically obstruct acetylcholine entry to the acylation site, and/or reduce its affinity by charge repulsion, thus explaining the inhibition of AChE enzymatic activity observed in the presence of fibrillar conformers, or in different prion-infected mice tissues.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com