Exact(1)
We propose that the adherens junction formed between the niche component (hub cells) and stem cells (GSCs) serves as a platform for multiple functions essential for stem cells: 1) maintenance of stem cells within the niche by physically anchoring the stem cells, 2) polarization of stem cells with respect to the niche, and 3) localization of factor(s) required for monitoring stem cell polarity.
Similar(59)
We further show that Rho1 facilitates Dia apical targeting, both by inducing the Dia open conformation, thereby exposing N-terminal domains that are critical for localization, as well as by physically anchoring Dia to the apical surface.
The cell's ability to sense mechanical cues from the ECM is made possible by engagement and clustering of integrins and formation of focal adhesions, which physically anchor the ECM to the actin cytoskeleton.
Dia apical targeting also depends on binding to Rho1, which is critical for activation-induced conformational change, as well as physically anchoring Dia to the apical membrane.
Though physically anchored to the floor, "Mind'Space" uses information technology to elasticize space and time.
By Dan Baum Joann Guidos, of New Orleans's Faubourg Marigny neighborhood, is a big woman with a piercing stare, the bark of a football coach, and a way of hugging people as though she intended to keep them physically anchored to the earth.
By using physically anchored markers it was possible to compare results across populations.
Thus, apically-localized Rho1 functions to physically anchor Dia to the apical surface, in addition to opening the protein.
Overall, 48 of a total of 164 contigs of the 5DS preliminary map were physically anchored by at least 1 molecular marker via Polymerase Chain Reaction (PCR) (Additional file 4).
The physically anchored block copolymer structure combines low elastic modulus (isoprene block) and creep resistance (styrene block) imparting inherent adhesiveness to SIS.
The first physically anchored hexaploid oat map has been recently completed [ 28].
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