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Apart from the mentioned tools, the burden of the diagnosis still rests mainly on the signs and symptoms elicited by physical examination of the patient.
The clinically node negative patients in the AMAROS, ACOSOG Z0011 and IBCSG 23 01 trial were selected by physical examination of the axilla.
Complaints could not be provoked by physical examination of the hips: there was pain-free and full range of motion and the femoro-acetabular impingement test was negative.
Absence of arthritis was independently confirmed by physical examination of 44 joints [ 7] by a trained medical doctor (WB or LAS) and a senior rheumatologist (DS).
Tumor relapse was detected by physical examination of the tumor site and regional lymph node and by computed tomography scan of lungs by the standard procedure.
Efficacy of treatment was assessed twice by physical examination of the udder, bacteriological culturing and determination of SCC and NAGase activity in milk about 2 weeks (mean 14.9 days, min. 10 days, max. 23 days) and 4 weeks (mean 29.2 days, min. 26 days, max. 37 days) after the beginning of the treatment.
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Presence of at least a 2 × 2 cm in diameter single lymph node or equivalent volume of nodes accessible by physical examination for excision, for histological confirmation of diagnosis, and for manufacture of the vaccine.
All patients were evaluated by physical examination, determinations of serum levels of electrolytes, urea, creatinine, acid-base balance.
Judgment of enlargement of the sublingual glands was by physical examination because of the difficulty in measurement by imaging.
At each examination, participants were followed up by physical examination, updating of medical history, and measurement of biomarkers.
Subjects in both groups were medically healthy (assessed by physical examination, review of systems and screening laboratory tests), had no acute illnesses or infections, and had not had any vaccinations within 6 weeks of entering the study.
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