Sentence examples for by perturbing the function from inspiring English sources

Organic small molecules generally act by perturbing the function of one or more cellular target proteins, the identification of which is essential to an understanding of the molecular basis of drug action.

These therapeutic RNA decoys and aptamers block HIV-1 transcription by perturbing the function of TAR.

Sub-inhibitory concentrations of tea CAs have also suppressed the opportunistic pathogen S. aureus to β-lactam antibiotics and relatively low concentration of epicatechin have sensitized MRSA clinical isolates to levels of oxacillin by affecting both virulence and antibiotic resistance by perturbing the function of key processes associated with the bacterial cytoplasmic membranes [ 35].

The parameters of the orientation-dependent function were optimized by simultaneously minimizing the RMSD of the lowest energy rotamer at each modeled position and the RMSD of the lowest energy decoy obtained by perturbing the energy functions and then modeling the entire protein.

The parameters of the orientation-dependent functions were optimized so that decoy proteins with low RMSD (root mean square deviation) from native structures could be distinguished from a pool of decoys (obtained by perturbing the energy functions and then modeling the entire protein).

Mutations in the Drosophila tip-E (temperature-induced paralysis) gene, which encodes a sodium channel auxiliary subunit, disrupt nerve conduction by perturbing the expression and function of the para voltage-gated sodium channel [ 63- 67].

If the oxidant serves as a negative heterotropic effector by perturbing the membrane-anchorage functions of the noncatalytic domains of RasGEFs, RasGEFs cannot be recruited for the plasma membrane and activated.

The E6 and E7 proteins from high risk HPVs mediate the oncogenic properties of the virus, in large part, by perturbing the cell cycle regulatory functions of the p53 and Retinoblastoma (pRB) tumor suppressor proteins, respectively.

This suggests that Daunorubicin may exert its anti-cancer function by perturbing the same two pathways.

It is possible that disease-causing mutations may function by perturbing the local environment near the organizing F-helix, which is responsible for maintaining structural plasticity and correct positioning of the key catalytic and regulatory spine regions [85] [87].

They function by perturbing the cellular machinery responsible for maintaining DNA structure during transcription and replication.