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Dopamine supersensitivity has been conceptualized as the increase in D2R number or biological action, and may be triggered by persistent reduction of D2R activity, as in the case of chronic treatment with D2R-blocking agents.
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Persistent reduction of hepatocytes, gradual proliferation of cholangiocytes, and continuous infiltration of neutrophils were noted in BDL alone rats.
Another significant alteration in striatal NMDA receptor function is the early and persistent reduction of Mg2+ sensitivity (Table 1).
This is followed by a persistent reduction in mEPSC frequency by 9 10 days post-injury (Li et al., 2009).
Beyond a transient effect of slowing down adaptation, transformation may also lead to a persistent reduction in mean fitness of the population when there is spatial heterogeneity, caused by the biofilm structure, in selection pressure.
Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters.
We then applied one assimilative model (ARM) to the Lake Michigan basin and found that there was persistent reduction in the amount of precipitation that becomes runoff following 1998, corresponding to a period of persistent low Lake Michigan water levels.
Moreover, loss of glucose causes mild but persistent reduction in body weight and concomitant fluid loss can reduce blood pressure.
Induction of RNAi in these cells results in a persistent reduction in growth rate after 24 h (Fig. 6A), which is preceded by a strong reduction in the levels of TbKIN13-1 in cells (Fig. 6B).
A persistent reduction in parenting stress has already been reported in our study by mothers in the intervention group, compared to mothers of preterm controls [ 26, 27].
The persistent reduction in synapse number occurred in the proximal dendrites, but not the distal dendrites, and was prevented by simultaneous application of the group I/II mGluR antagonist (S -a-methyl-4-carboxyphenylglycine (MCPG).
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