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We developed the third approach by performing pathway analysis using Panther [ 28] and MetaCore (GeneGo Inc).
Biological processes in which differentially expressed genes are enriched were identified by performing pathway analysis in PathVisio.
In this study, we sought to gain a comprehensive understanding of the key driving pathways for osteosarcoma by performing pathway analysis of recurring gene copy number aberrations using array comparative genomic hybridization (aCGH) analysis.
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By studying gene-expression profiles and performing pathway analysis, we have identified the importance of an IFN-β-dependent pathway as one molecular mechanism for the arthritis-ameliorating efficacy of NADPH oxidase-activating compounds.
In keeping with this, we discovered significant enrichment of HoxA7-driven (Z-score: 2.746; p=1.63 × 10−8) and HoxA9-driven (Z-score: 2.314; p=1.13 × 10−3) gene expression networks by performing pathway enrichment analysis with the 'Ingenuity Systems' pathway analysis tool.
For further insight into genes regulated by UCH L1, we performed pathway analysis using the Ingenuity Pathway Analysis (IPA) [40], (www.ingenuity.com).com
> -wrap-foot> We performed pathway analysis by testing 1833 gene sets for an excess of genes hit by CNVs in cases.
R.S.N.F. and H.R.d.B. performed pathway analysis.
S.M. and Y.L. performed pathway analysis.
KOBAS (http://kobas.cbi.pku.edu.cn/home.do) was used to perform pathway analysis.
By performing pathway meta-analysis, we have identified several pathways involved in breast cancer metastasis.
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