The method works by performing a rapid computational screening of tens of thousand of mutations to identify those with the greatest impact on the solubility of the target protein while maintaining its native state and biological activity.
In summary, we predicted EZH2-silencing targets and their functions in t-AML by performing a novel computational integrative analysis.
By performing a range of computational analyses, we were able to consistently link Tdg KO-associated DMRs with regulation of transcription during developmental processes and regions involved in the maintenance of repressive chromatin, particularly those occupied with PRC2.
By performing a genome-scale computational analysis, we have tried to evaluate the role of antisense transcription in mediating sense transcription under different environmental conditions across and in two related yeast species.
Assuming that the native DNA sequences of highly expressed genes have evolved to exhibit optimal ICU and CC for high in vivo expression, we demonstrated the efficacy of our computational approaches by performing a leave-one-out cross-validation on the high-expression genes for each expression host.
These configurations are studied for their mixing performance by performing computational fluid dynamics (CFD) simulations of pulse tracer and flow visualization experiments, and using residence time distribution (RTD) and species mass fraction distribution (SMFD) as mixing characterization measures, respectively.
In this study, the effects of serpentine flow-field designs on the performance of a commercial-scale PEM fuel cell stack for micro-CHP (Combined Heat & Power) systems, which use reformed gas as fuel, are investigated by performing both computational fluid dynamics (CFD) simulations and experimental measurements.
Absolute permeability is computed by performing Computational Fluid Dynamics CFDD) simulations of single-phase incompressible flows in the reconstructed pore space.
When a number of promising hypotheses have been formulated, the computer can test those hypotheses quantitatively by performing computational and statistical tests on various trajectory features.
