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Ethanol production yield and efficiency was enhanced by pathway engineering in the engineered strains.
First, Escherichia coli was engineered for lycopene synthesis by pathway engineering.
l-glycerol 3-phosphate (l-G3P) was accumulated in Saccharomyces cerevisiae by pathway engineering.
The set of all genes with counteracting function is identified by pathway searches.
Metabolic flux analysis with 13C isotope studies confirmed that the increase in lysine production was mediated by pathway coupling.
In this study, we attempted to achieve microbial production of GlcNAc by pathway engineering of Bacillus subtilis 168.
Dynamic reorganization of signaling systems frequently accompanies pathway perturbations, yet quantitative studies of network remodeling by pathway stimuli are lacking.
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The pathway analysis was done by Pathway-Express [ 17, 18].
Gene-oriented models of CRC progression are being replaced by pathway-oriented models.
Glycolysis was detected as significantly down-regulated in the SALS motor cortex by pathway-based analysis of our microarray data.
Our method may also have useful predictive value for other phenotypes influenced by pathway-level changes, such as cancer biology.
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