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Our aim was to examine effect of mGlu2 PAMS in facial allodynia model induced by partial ligation of infraorbital nerve (pIONL) in rats.
Tormentic acid (30 mg/kg, p.o). and gabapentin (70 mg/kg, p.o)., given twice a day, inhibited markedly the neuropathic allodynia induced by partial ligation of the sciatic nerve, with inhibition of 91±19% and 71±16%, respectively.
injected pregabalin reduced thermal and mechanical hypersensitivity in a murine chronic pain model that was prepared by partial ligation of the sciatic nerve (the Seltzer model), suggesting that pregabalin acts at both supraspinal and spinal loci.
Experiments were designed to address whether the pentacyclic triterpene tormentic acid isolated from the stem bark of the plant Vochysia divergens exerts oral anti-allodynic properties in two models of chronic pain in mice: neuropathic pain caused by partial ligation of the sciatic nerve and inflammatory pain produced by intraplantar injection of Complete Freund's Adjuvant.
The rapid paravascular influx of HRP could be prevented by halting or diminishing the pulsations of the cerebral arteries by aortic occlusion or by partial ligation of the brachiocephalic artery.
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In the present study, we employed an early AS model in rats which was induced by a high-fat diet, partial ligation of LCCA and vitamin D3 injection to investigate the joint effect of combined Chinese medicine and exercise training.
The findings from Yun You [ 28] indicated that the combined therapy of oral Chinese medicine with swimming can inhibit inflammatory factors, improve hemorheological parameters and lipoproteins in a rat AS model induced by combination of low shear stress resulted from partial ligation of common carotid artery with afterwards feeding of a hyperlipotic diet.
Partial ligation of the sciatic nerve was performed by tying the distal 1/3 to 1/2 of the dorsal portion as previously described.
Male C57BL/B6 mice (30 g) were subject to partial ligation of the left carotid artery [33] and FVB/N mice were injured by complete ligation of the common carotid artery [59].
Partial ligation of sciatic nerve significantly increased the phosphorylated proportion of NR1 and NR2B subunits in the dorsal horn.
However, the Nav1.8 null mice showed normal hyperalgesia in the early days after partial ligation of sciatic nerve[ 17].
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