By contrast, partial inactivation of PKA confers rapamycin hypersensitivity but only modestly affects RP gene expression.
While neuronal expression of human Aβ42 increased caspase 3/7 activity by 20% in fly heads by 20 DAE, systemic partial inactivation of dTSPO (tspo +/−) and neuron-specific knockdown of dTSPO returned the caspase activity to that of normal brain tissue (Fig. 5D).
We have previously shown that JAK/STAT, IRAK-1 and MAP kinases signalling pathways are rapidly altered by Leishmania, leading to partial inactivation of various transcription factors such as STAT-1α, AP-1 and NF-κB [2], [3], [4].
More direct evidence that p53 may be dispensable for sensitivity to Cisplatin in TGCT cells came from Burger et al.: partial inactivation of p53 by HPV16-E6 iNTERA-2D1D1 cells did not render these cells more sensitive to Cisplatin [20].
Partial inactivation of genes by HIGS has potential for examining the importance of rust fungus genes with unknown functions while growing within host plants [ 18, 19].
It is likely that the slow depolarization evoked by a long pulse leads to a partial inactivation of Na+ channels and activation of KA channels prior to spike initiation, and therefore, increases the firing threshold and delay.
We wondered if the specific and general downregulation of miR-17-92 miR-17-92 miR-17-92the partial inactivation of c-membersHQ17(3).
Whether lack of activation or partial inactivation of PKN2 and PKN3 by PIP3 or other lipids is a physiological response, and a marker of non-redundant functions between the PKN isoforms, remains to be investigated.
Partial inactivation of Dido gene products, by truncation of the N-terminal domain common to the three Dido isoforms (Dido3ΔNT), impairs the SAC machinery and provokes centrosome amplification, spindle malformation, aneuploidy and DNA damage.
Miao, C. et al. Hippocampal remapping after partial inactivation of the medial entorhinal cortex.
