Sentence examples for by oxidative modification of from inspiring English sources
Indeed, severe oxidative stress conditions resulted in a drastic drop in the apoptosis (i.e. GOx 50 mU/ml and 1600 μM), consistent with the notion that pro-oxidant conditions can inactivate caspases by oxidative modification of key cysteine residues, thereby impairing the apoptotic program and promoting a switch to necrosis [ 5].
Because fragmentation of ApoB can also be caused by oxidative modification of LDL [ 21], the inhibitory effect of LJT on LDL oxidation was also evaluated by fragmentation of ApoB using electrophoretic analysis on SDS-PAGE.
To overcome these issues, we have investigated the anti-angiogenic properties of a series of stable derivatives obtained by oxidative modification of the natural product.
To identify the reactive group(s) mainly involved in this anti-angiogenic effect, we have investigated the anti-angiogenic properties of a series of stable derivatives obtained by oxidative modification of the natural product.
Based on these in vitro findings, we hypothesize that ROS can directly affect GTPase activity in cells by oxidative modification of the critical cysteine residues within the redox-active motif.
By contrast, our report unveils an intrinsic signal formed by oxidative modification of the client protein instead of the chaperone.
Perhaps, as it is conceivable that endocytosis is triggered by oxidative modifications of lipids or proteins that are brought to the cell surface during hypoxia.
Available data suggest that IRP2 is highly sensitive to ROS-induced downregulation; this may be triggered by oxidative modifications of sensitive residues and could lead to ubiquitin-dependent proteasomal digestion (Ref. 30) (Fig. 2).
However, loss of CK-B activity by oxidative stress appears to be caused by posttranslational oxidative modification of the enzyme [19].
