Sentence examples for by overrepresentation of binding from inspiring English sources
The finding that Dichaete binding locations are marked by overrepresentation of binding motifs for factors defining HOT regions, coupled with the widespread gene expression effects of Dichaete mutations, suggests that Dichaete may also play a role in regulatory interactions at HOT enhancers.
The overrepresentation of binding sites was quantified using z-scores (Table 1).
Had we claimed overrepresentation of binding sites in the first 2000 bp, discovery bias would have been a valid concern.
Altogether, overrepresentation of binding sites in promoters of DE genes detected biologically meaningful transcription regulators, which further support the results of other parts of this study.
Complementary to gene ontology functional overrepresentation analysis, GSCA calculates overrepresentation of binding events for a gene list of interest, thus predicting possible transcriptional control mechanisms.
The core Dichaete binding intervals we identified are enriched for Sox binding motifs but we also found significant overrepresentation of binding motifs for Vfl, the GAGA-binding factor Trl and the JAK-STAT pathway transcription factor Stat92E.
These results cannot be explained by overrepresentation of certain functional categories among younger or older genes.
Off-targets of NKX2-5 mutants, but not those of an NKX2-5 YRD mutant, showed overrepresentation of ETS binding sites and were occupied by ETS proteins, as determined by DamID.
It is a standard approach to test for overrepresentation of TF binding sites in promoters of coregulated genes versus a background of promoters.
Although our method identifies overrepresentation of a binding site in a GO-based functional group, we can use the information also for identification of BSs on particular promoters.
Therefore, F-MATC Hadopts the strategy of iterating over score thresholds to optimize the overrepresentation of predicted binding sites for each specified PWM.
