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By our study design, it is impossible to prove or refute previous findings suggesting a decline in medical costs after diagnosis.
We are therefore limited by our study design to restrict our discussion only to the tumor aspect of predictive dosimetry; our study cannot draw conclusions on predictive dosimetry applied to non-tumorous liver or lungs.
Primary ICU-BSI was observed in 31.6% of our cohort, which is similar to the study by Stohl et al. [25] but higher than some reports [22],[27] and may be partially explained by our study design, with paired cultures not mandated.
Our study showed that although factors such as preanalytical sample handling and lot-to-lot variability were minimized by our study design, we identified high variation in absolute values of CSF aSyn even when the same samples and same lots of assays were applied.
One limitation to this study is the ascertainment bias introduced by our study design.
This late increase was not covered by our study design.
Similar(41)
High prevalence of active TB among FDR contacts could be explained by the nature of our study design by selecting and evaluating only FDR contacts of index case households where one or more individuals had potential TB symptoms.
Secondly, by nature of our study design, a cause effect relationship between a pro-inflammatory status and adverse outcome cannot be established.
By closely analyzing our study design, we suspected that the implemented teacher behavior in extracurricular settings might not have been appropriate.
While our findings are limited to soft substrates and influenced by sampling restrictions, our study design allowed us to put bounds on our estimates based upon these multiple sources of uncertainty.
Subtle reductions in IQ are an attribute of BD (Cardenas et al. 2016) and do not appear by chance due to our study design.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com