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This biochemical observation can now be explained by our evolutionary analysis.
Given this number of sensitive positions predicted by our evolutionary analysis, the mutation is validated as being responsible for the AI and this region as playing an important role during enamel matrix formation.
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Our evolutionary analysis is limited by the amount of information that can be managed in a single study, with the focus fixed upon the domain Bacteria (due to the relative density of genome representation for Bacteria in the public databases).
Our evolutionary analysis suggests that diversifying evolution occurred by positive Darwinian selection, rather than the random fixation of neutral mutations.
6) We assessed the rate and time scale of evolution by applying Bayesian Evolutionary Analysis by Sampling Trees (BEAST) in the one patient series with a sufficient density of longitudinal samples and have included that analysis.
Samples with discordant results were sequenced and their genotypes were determined by molecular evolutionary analysis.
This was also verified by the evolutionary analysis of ORF5, a putative virulence marker at the amino acid level (Fig. 6B).
To gain an overall insight into zebrafish SET domain genes and to evaluate the evolutionary conservation of them with their human counterparts, we firstly performed a genome-wide survey of SET domain genes of zebrafish, followed by an evolutionary analysis of these genes between zebrafish and human.
Notably, DNA-DGGE profiles (Fig. 1a) fully segregated according to insulin-sensitive (IS) or insulin-resistant (IR) phenotypes, as shown in Fig. 1b by the evolutionary analysis based on Pearson's tree method.
In future, the discovery of isolates of M. robertsii and M. acridum with complementary MAT idiomorphs followed by evolutionary analysis of these idiomorphs may help to further our understanding of the role of MAT1-1-2 in the Metarhizium species complex, and the potential effect on genetic exchange and perhaps, the observable phenotypic variation between cultures.
By using an evolutionary analysis of the spatial structure of the waterfront landscape, it demonstrates that government development agencies and event tourism have been the key agents of change in influencing its redevelopment at different phases.
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