Interestingly, whereas TLR receptor-proximal signaling and cytokine production were clearly changed by SMPDL3B depletion, other processes, including TLR4 surface expression and endocytosis or CpG uptake, appeared normal.
A second genetic process that may help to explain an enrichment of positive selection on polygenic disease genes is balancing selection mediated by antagonistic pleiotropy, or other processes including overdominance or frequency-dependent selection.
The nature of the symptoms reported in the oral iron group is not surprising as iron that remains soluble in the intestinal lumen is likely to be bioavailable but, equally, may be available for other processes including uptake by commensal flora and colonic epithelial cells, and facile redox-cycling in the gut lumen.
All other processes including "Lipid Metabolism" and "Inflammatory Response" were affected by rosiglitazone to greater extent than by pioglitazone.
Other processes include acetaldehyde oxidation and ethane partial oxidation.
Other processes include precipitation of surfactants and phase trapping.
Diversity at the recombination level is further enhanced by other processes that include the exonuclease digestion (trimming) of 3'-V, 5'- and 3'-D, and 5'-J genes, the imprecise joining of nicked genes, and the addition of non germline nucleotides (N nucleotides) at the V-J, V-D and D-J junctions.
In addition, a crucial question for the maintenance of polymorphism is to what extent frequency-dependent foraging by visual predators is counteracted by other selective processes, including non-visual predation.
Near-surface karst is modified by other geomorphic processes, including fluvial action and glaciation.
Dysregulation of angiogenesis in systemic sclerosis is accompanied by other pathogenic processes, including fibrosis, autoimmunity and vasculopathy.
