Sentence examples for by other functional polymorphisms from inspiring English sources

The complex relationship between folate intake and CRC risk may be further modulated by other functional polymorphisms impacting on folate metabolism.

Although intronic polymorphisms can affect gene expression by various mechanisms [ 47], there is no evidence that rs761142 is functional by itself; instead, the association observed in this study could be caused by other functional polymorphisms in LD with rs761142 responsible for lowering GCLC mRNA expression.

However, if rs2867461 and rs2293347 have no function, these SNPs are possible predictive factors linked with other functional polymorphisms in ANXA3 and EGFR, respectively.

We hypothesize that some statistically significant independent genetic effects may fail to replicate in an independent dataset when allele frequencies differ and the functional polymorphism interacts with one or more other functional polymorphisms.

It is also possible that these polymorphisms are in linkage disequilibrium with other functional polymorphisms that may affect BC susceptibility.

To date, no other functional polymorphisms within the COMT gene has been linked to chronic MSCs.

An alternative explanation is that it is in LD with other functional polymorphisms nearby.

The observed association with the 4G/5G polymorphism may be due to its linkage disequilibrium with other functional polymorphisms in the PAI-1 gene.

A third possibility is the presence of other functional polymorphisms that we did not detect in the present study.

This is quite possible, because our correlation analysis also pointed to the presence of other functional polymorphisms.

Whether the COX-2 8473T>C polymorphism itself alters mRNA stability and/or translation efficiency or if it is in linkage disequilibrium with the other functional polymorphisms remains to be investigated.