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For instance, the bicistronic miR-143/145 miRNA gene cluster dictates smooth-muscle cell phenotypic switching by orchestrating the expression of a cadre of cytoskeletal remodeling regulators (Xin et al., 2009).
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Furthermore, we demonstrate that miR-142-3p miR-142-3p miR-142-3psynthesis by orcontrolsing the coordinated explatelet of several distinct nodes in a network of actin cytoskeleton regulators.
The molecular mechanisms underlying the response to hypoxia are extremely complex, and a key role is played by HIF, which orchestrates the expression of a wide variety of genes thought to be critical for adaptation to hypoxia.
As well as adding to our knowledge of circadian biology and the nuclear envelope, this study reveals a mechanism by which cells can orchestrate the expression of large numbers of genes.
It was reported that a single miRNA can orchestrate the expression of several genes and a single gene can be regulated by a set of different miRNAs [ 20– 20].
MicroRNAs are relatively stable in body fluids orchestrating simultaneously the expression of many genes.
MicroRNAs orchestrate the expression of the genome and impact many, if not all, cellular processes.
Here, we revealed that PPAR γ regulates skin wound macrophages TNF- α expression by orchestrating their phagocytic function.
Thus, by directly activating the expression of these EMT early drivers, P-TEFb is capable of orchestrating the EMT program to drive malignant progression.
Although REST and CoREST are believed to orchestrate neurogenesis by regulating the expression of neuronal differentiation genes, our ChIP-chip studies suggest that these factors are also important for modulating NSC-mediated glial lineage specification and maturation.
"No, the Americans provoked first, by orchestrating Ukraine," he said.
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