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Of note, companies have minimized or overcome some adverse events by optimizing the dose and posology.
Altogether, our results demonstrate that the combination of IR and angiogenesis inhibition can be improved by optimizing the dose and scheduling of both treatment modalities.
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Browder in the Folkman laboratory was the first to demonstrate the concept that by optimizing the dosing schedule of conventional cytotoxic chemotherapy to achieve more sustained apoptosis of endothelial cells in the vascular bed of a tumor, it is possible to achieve more effective control of tumor growth in mice, even if the tumor cells are drug resistant [ 54].
By optimizing the ozone dose, the modifications of ACF properties due to O3 and OH oxidation could be minimized.
When optimizing the dose to the constraint-lung was reduced by setting a higher level of dose constraints as a more effective method to reduce the doses to the ipsilateral lung and heart and increase the PTV dose conformity.
With the advent of conformal 3D-treatment planning precise physical dose localization can be achieved optimizing the dose distribution.
Further increases in yield might be achieved by optimizing the concentration and dosing method of the inducer and the timing of induction.
We predict that the concentration of anti-HA antibodies can be increased by optimizing the GP42-H1 vimmunizingizing dose; however, immunization with 1,000 pfu for GP42-H1 wasufficientntoto induce protection.
Therefore, it could be further improved probably by optimizing the time of exposure and dose for effective pre-treatment.
This problem was solved by optimizing the synthesis of ZnO.
These parameters have been estimated by optimizing the prediction process.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com