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This way, by comparing factors secreted by G2B-10A versus R2-T1AS cells alone, we were able to establish whether any factors represented on the array were specifically secreted by one cell type or the other.
Recently, we discovered that dense concentrations ("hotspots") formed by both immune and cancer cells, rather than those formed by one cell type alone, are associated with good prognosis in estrogen receptor (ER -negative brER -negative[ 16].
While most soluble mitogenic growth factors (GFs) are made by one cell type to stimulate proliferation of another, many of the growth signals can drive the proliferation of carcinoma cells, thus allows cell proliferation in specific phase of tumor development [11].
There is then a complex interplay within the tissue microenvironment whereby cytokines and chemokines secreted by one cell type further impact the effector function of other cells types, and in turn, immune mediators can also feed back and impact the gut microbiota (Fig. 2).
Although a great deal is known about the role of different signaling pathways for development and maintenance of different cells and tissues, it remains challenging to hierarchically connect different levels of cell communication to clearly understand how signals received by one cell type are transmitted to regulate the fate of another cell.
Since resident and mutant cells grow exponentially with different growth rates, we expect that tumors will most often be dominated by one cell type: for short times, tumors will consist mostly of resident cells; for long times, they will consist mostly of mutant cells (Fig. 3).
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Articular cartilage is commonly described as a tissue that is made of up to 80% water, is devoid of blood vessels, nerves, and lymphatics, and is populated by only one cell type, the chondrocyte.
These oligosaccharides were produced by only one cell type, therefore, different kinds of oligosaccharides can be produced using various cells.
Initially, we attempted to identify a sorting pattern by labeling one cell type with CellVue Claret (CVC).
However, tissue pathology is often caused by a combination of factors that are produced by more than one cell type.
Previous experiments had focused mainly on obtaining one cell type.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com