Animal experiments demonstrated the great efficiency of this drug by curing 90% of mice from growing tumors without inducing any observable side effects.
Herein, we found that in female mice, fasting for 48 h before a single dose of DXR decreases the early observable side effects of the drug, i.e., freezing behavior, ruffled hair, and hunched back posture.
Locally infusing anisomycin into the OB caused no observable side effects in that the treated animals were able to perform basic processing of an olfactory cue and showed no alteration in their locomotive or exploratory behavior.
YSL is novel anti-tumor peptide that can inhibit the growth of human hepatocellular carcinoma cells without observable side effects.
Common observable side effects and neuropsychiatric signs include dry mouth, drowsiness, agitation, anxiety, hyperactivity, ataxia, and loss of memory [ 22].
Systemic delivery of synthetic miR-29b mimic increases miR-29b levels in vivo for several days without observable side effects or effects on gene expression.
We also conducted a toxicology study in pre‐clinical animal models according to Good Laboratory Practice (GLP) standards and found no observable side effects (data not shown).
Administration of DAP5 reverses these devastating effects, without any observable side-effects.
In this pilot study, we found that GOS was well accepted and tolerated by newborn foals, causing no observable negative side effects.
In human volunteers, oral administration of melatonin for a wide dosage range of 1 300 mg, and even up to 1 gram per day, for 30 days [ 85] resulted in no observable negative side effects [ 7].
