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The enzymes involved, their site of action, essential transporters and exact conjugating enzymes have been characterised, and in vitro mechanistic experiments have been supported by numerous studies, using healthy volunteers, ileostomists, intestinal perfusion, and animal models.
Sleep disturbances are common in critically ill patients and have been characterised by numerous studies using polysomnography.
The importance of mitochondria-mediated death signals for stress-induced death have been demonstrated by numerous studies using cells either overexpressing antiapoptotic BCL2 family members such as BCL2L1/BCL-xL or cells lacking integral proapoptotic proteins such as CASP9-deficient (casp9−/−) mouse embryonic fibroblasts (MEFs) or BAX and BAK1 double knockout (bax −/− bak1−/−) MEFs.
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This relationship was first reported for Drosophila by Shields et al. (1988), and numerous studies using diverse approaches have supported the hypothesis that natural selection influences codon usage in several Drosophila species (Kliman and Hey 1993; Akashi and Schaeffer 1997; Carlini and Stephan 2003; Haddrill et al. 2011; De Proce et al. 2012).
However, there are numerous studies using various surface modification methods have been published.
There are numerous studies using this peptide with the 68Ga radionuclide (Ghosh and Heston 2004).
There are numerous studies using this peptide with the 68Ga radionuclide.
This building has been the focus of numerous studies using the WiSE ray-tracing tool [13 15].
The loss of aerated lung volume is the cardinal feature of ARDS as demonstrated by numerous studies that used lung computed tomography (CT) scan [1 3].
The loss of aerated lung volume is the cardinal feature of ARDS as demonstrated by numerous studies that used lung computed tomography (CT) scan [ 1- 3].
Their role and importance has been highlighted by numerous studies associating their use with clinical reductions in hospital-acquired infections (HAIs) [ 1, 2].
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