For example, there may be changes in requirements for micro-dissection to isolate tumor tissue from contamination by normal tissue for a test of somatic mutations, or changes in the buffer conditions to stabilize a sample during transfer to a reference laboratory.
It is thought that the pegylated liposomal formulation may improve specificity of delivery to tumours, decreasing absorption by normal tissues, and may decrease many of the dose-limiting side effects of doxorubicin (Goram et al, 2001).
Whereas the tantalum pellets in the low-dose group were surrounded by normal tissue, all of the tungsten alloy and nickel pellets were surrounded by tumors.
The reports available [ 52] stress the importance of high expression of aromatase in the uterine myoma cells, accompanied by residual expression in normal tissues of the myometrium.
The number of TF genes that met our criterion for expression in normal or adenomatous colorectal tissue (or both)—1218 was thus markedly higher than those reported by Vaquerizas et al. in normal tissues of other organ systems, which ranged from 150 to 300 [ 15].
Promoter hypermethylation of at least two of these genes occurred most frequently in breast cancer (78% of samples, N = 27) followed by normal tissue from cancer patients (40% of samples, N = 17) and at the lowest frequency in normal tissue from unaffected women recruited from a breast cancer risk assessment clinic (24% of samples, N = 55).
A tissue microdissection technique was applied to primary tumor tissues to reduce the contamination of samples by normal tissue components.
A tissue microdissection technique was used to reduce the contamination of samples by normal tissue components for array CGH analyses, as previously described [ 16].
Our expression data are supported by the normal tissue sources of EST sequences in UniGene folders Hs.160594 and Mm.295937, all of which have been isolated from testis (or pooled samples containing testis).
In a small-scale study performed by northern blot analysis on normal tissues, expression of the transcription factor RHOXF2 was initially reported to be restricted to testis [ 35].
