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Pregnancies in hypercholesterolemic and atherosclerotic females were characterized by normal numbers of fetuses and occasional resorptions, discarding a gross effect of this pathological metabolic condition on inhibition of implantation or abortion.
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Immunostaining further revealed almost normally shaped and sized MBL surrounded by normal number of CK-positive cells, and well-defined FBV space surrounded by normal number of laminin-positive cells, suggesting that severe defects in the branching of labyrinth in Shh−/− placentas were almost completely rescued by Gli3 knockdown.
By contrast, normal numbers of macrophages and neutrophils were found in spleens of ptpn11 fl/fl ert2-cre mice (Fig. 3B).
By contrast, there were normal numbers of T cells and Ter119+ cells.
In this system, inhibition of alpha-1,2-mannosidase by KIF is transient, as by 15 days post-transplant normal numbers of TregKIF are present in the ALN and they have the correct N-glycan signature (data not shown).
Intact act-1 (RNAi) animals displayed normal numbers of X1 cells as counted by flow cytometry.
Indeed, TgS100a8a9 hep mice with repressed transgene expression exhibited baseline Cxcl1 transcript levels in the liver, accompanied by a normal number of neutrophils in peripheral blood.
Heterozygous familial hypercholesterolemia is an autosomal dominant disorder characterized by half the normal number of low density lipoprotein (LDL) receptors and markedly elevated LDL cholesterol levels.
In this manner, the smaller size of the wing is caused by both a lower than normal number of cells and by a reduction in cell size.
Strikingly, sFRP-3 reverted this inhibitory activity by causing the appearance of a normal number of follicles in the presence of EGF, without any effect on its own.
These follicles likely result from the encapsulation of two germline cysts together in the germarium as evidenced by the presence of twice the normal number of nurse cells (Figure 1C) and the presence of two oocytes, the latter marked specifically by anti-Orb antibodies (Figure 1C″, arrows).
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