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It should be underlined that exosomes are also detected in normal subjects, being secreted also by normal cells of different organs, including blood cells.
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The compound may be taken up by tumor cells but not by normal cells because of a possible difference between the membranes of normal and malignant cells.
Control-FREEC detected somatic CNA and LOH regions covering 75% of the tumor genome (Fig. 1) and was able to identify the genotype status despite contamination of the tumor sample by normal cells (estimated percent of tumor cells was 60%).
Control-FREEC inherits many features from FREEC (Boeva et al., 2010) (assessment of copy number variation and evaluation of contamination by normal cells) as well as the general methodology of the GAP algorithm for SNP arrays (Popova et al., 2009).
We therefore hypothesize that the increased production of SPARC by normal cells may contribute to the efficacy of IM in reducing CML clone.
This revealed that when surrounded by normal cells, the high levels of Yap in individual cells do not lead to excessive liver growth.
In that strategy, replacing deficient macrophages and microglia by normal cells combines the advantage of furnishing the tissues and particularly the brain with a critical enzyme source, with the potential restoration of scavenger function [ 43, 64, 81].
Sun et al. reported that after intravenous administration of PTD4 apoptin, the protein uptake by normal cells may limit the efficient accumulation of apoptin in cancer cells (Sun et al. 2009).
Since the lost allele in these regions has zero copies, any signal would be attributed to contamination by normal cells (which have one copy of each allele).
It characterises copy number, loss of heterozygosity, intratumour heterogeneity and the degree of contamination by normal cells.
The reason may be that the cancers are solid tumors, infiltrated by normal cells, and in many cases injections of the virus may not have reached all parts of the tumors.
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