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Pharmacokinetic parameters were determined by noncompartmental methods using WinNonlin (Version 3.0, Pharsight Corp., Mountain View, CA, USA).
The pharmacokinetic parameters of ramosetron were analyzed by noncompartmental methods using WinNonlin version 6.3 (Pharsight Co., Mountain View, CA, USA).
Plasma pharmacokinetic parameters – area under the curve (AUC), maximum concentration (Cmax), time to maximum concentration (tmax), and apparent terminal half-life (t1/2) – for BAY 43-9006 were calculated by noncompartmental methods using KINCALC (a program developed by Bayer HealthCare).
Standard PK parameters (area under the concentration time curve [AUC], maximum serum concentration [ Cmax], time to Cmax [ Tmax], apparent terminal elimination half-life [ T½], AUC0-inf and AUC0-last) were calculated by noncompartmental methods using WinNonlin 6.0 (Pharsight Corporation, St . Louis MO).
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ZNM pharmacokinetic parameters were estimated by standard noncompartmental methods using Kinetica software, version 5.1 (Thermo Fisher Scientific, USA).
TPM pharmacokinetic parameters were estimated by standard noncompartmental methods using Kinetica software, version 5.1 (Thermo Fisher Scientific, USA).
The pharmacokinetic parameters were calculated from the KAF156 plasma concentration actual-time data for subjeconcentration actual-timent by standata noncompartmental methods using WinNonlin Phoenix (version 6.2).
PK variables were calculated by standard noncompartmental methods using WinNonlin profession (version 6.3) as previously described (Adjei et al, 2008; Gabrielsson and Weiner, 2012).
Concentration time data of irinotecan, SN-38, and R115777 were analysed by standard noncompartmental methods using the software package WinNonlin version 3.1 (Pharsight, Mountain View, CA, USA).
Pharmacokinetic parameter estimates were calculated according to standard noncompartmental methods using WinNonlin software (version 5.1.1; Pharsight Corporation, Mountain View, CA) and summarized by dose level.
The PK parameters of matuzumab were calculated according to noncompartmental methods using the PK software program Kinetica, version 4.1.1.
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