Sentence examples for by mutations that prevent from inspiring English sources

Constitutively active Ras is typically caused by mutations that prevent GTP hydrolysis, thus locking Ras in a permanent 'on' state.

In certain instances, Cenani Lenz syndrome is caused by mutations that prevent Lrp4 from interacting with these negative regulators, leading to excessive Wnt and/or BMP signaling (Leupin et al., 2011).

Consistent with this model, ventral furrow invagination is blocked by mutations that prevent an initial stochastic phase of apical contraction of mesodermal cells [9], and these defects can be rescued by mechanical indentation, indicating that mechanical stimuli can coordinate morphogenetic movements locally.

Ndg Fkh1+2+3 was expressed in normal and additional CCs and Odd-PCs in the presence of ectopic Jumu (Fig. 5F-F″′; supplementary material Table S3), indicating that the repressive effect of Jumu is blocked by mutations that prevent Fkh TF binding.

That is achieved by acquiring mutations that prevent the shortening of the ends of chromosomes, or telomeres.

The lack of reversion within HLA-restricted HCV T-cell epitopes and viral adaptation sites may suggest that mutations at these sites have limited impact on viral fitness or the cost is offset by compensatory mutations that prevent simple reversion.

By introducing mutations that prevent SEPT9 self - association at the N- and C- termini, it has been shown that septin filament disruption causes defects in the late stages of cell division before abscission, similar to these observed upon SEPT9 depletion [ 28].

The predicament in prostate cancer is much the same: researchers and clinicians alike are forced to keep running merely to stay still, because the receptors targeted by prostate cancer drugs are continually undergoing mutations that prevent the drugs from working.

Limited recombination among targets of selection is also predicted to lead to reduced diversity, whether by selective sweeps that wipe out standing variation (Maynard Smith and Haigh 1974; Gillespie 2000) or by background selection against continually arising deleterious mutations that prevent diversity from accumulating in the first place (Charlesworth et al. 1993; McVean and Charlesworth 2000).

To test whether mutations that prevent processing are tolerated by P. falciparum, we adopted two complementary strategies.

Transformation by Ras can only proceed in the presence of additional mutations that prevent Ras-induced senescence.